To support the continuous development of PlantTFcat, please cite: Xinbin Dai, Senjuti Sinharoy, Michael K. Udvardi and Patrick X. Zhao, PlantTFcat: An Online Plant Transcription Factor and Transcriptional Regulator Categorization and Analysis Tool, BMC Bioinformatics, 2013, 14:321, doi:10.1186/1471-2105-14-321.
The Zhao Bioinformatics Laboratory
PlantTFcat: An Online Plant Transcription Factor and Transcriptional Regulator Categorization and Analysis Tool   
  About Analysis Family Help
Location:  Details of ISWI family

Family Type Chromatin remodeling
Plant Specific No
Functional Domains ATPase
Must-have InterProScan Domain Pattern IPR015194
Prohibited InterProScan Domain Pattern -

One of the best-conserved ATPase families involved in chromatin remodelling is the imitation switch (ISWI) family ISWI is a conditional ATPase that hydrolyzes ATP maximally only in the presence of nucleosomes, its natural substrate. In contrast, free histones do not affect the low basal level of ATP hydrolysis while free DNA triggers ATPase activity only modestly All ISWI proteins contain a conserved ATPase domain that belongs to the superfamily of DEAD?H (Asp-Glu-Ala-Asp ? His)-helicases [3,4], located in the N-terminal half of the proteins. In the C-terminal part, a HAND domain, a Swi3 Ada2 N-CoR TFIIIB (SANT) domain and a juxtaposed SANT-like ISWI (SLIDE) domain are present. ISWI chromatin remodellers not only play a role during chromatin (dis)assembly, as is the case in DNA repair or replication, but they can also switch nucleosome positions to block or clear promoters. This can directly change the expression level of the corresponding gene.


1. D. F. Corona, G. Langst, C. R. Clapier, E. J. Bonte, S. Ferrari, J. W. Tamkun, P. B. Becker, ISWI is an ATP-dependent nucleosome remodeling factor. Mol Cell 3, 239 (1999).

2. T. Grune, J. Brzeski, A. Eberharter, C. R. Clapier, D. F. Corona, P. B. Becker, C. W. Muller, Crystal structure and functional analysis of a nucleosome recognition module of the remodeling factor ISWI. Mol Cell 12, 449 (2003).

3. F. Erdel, K. Rippe, Chromatin remodelling in mammalian cells by ISWI-type complexes--where, when and why? Febs J 278, 3608 (2011).

Cross-reference to other databases

The family is only defined in PlantTFcat.

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