To support the continuous development of PlantTFcat, please cite: Xinbin Dai, Senjuti Sinharoy, Michael K. Udvardi and Patrick X. Zhao, PlantTFcat: An Online Plant Transcription Factor and Transcriptional Regulator Categorization and Analysis Tool, BMC Bioinformatics, 2013, 14:321, doi:10.1186/1471-2105-14-321.
The Zhao Bioinformatics Laboratory
PlantTFcat: An Online Plant Transcription Factor and Transcriptional Regulator Categorization and Analysis Tool   
  About Analysis Family Help
Location:  Details of bHLH family

  bHLH
Family Type Transcription factor
Plant Specific No
Functional Domains DNA binding domain
Must-have InterProScan Domain Pattern IPR011598
Prohibited InterProScan Domain Pattern -
Description

bHLH is a ubiquitously present DNA binding Domain. The bHLH domain is highly conserved and comprises ~ 60 amino acids. In bHLH domains there is at least five basic amino acids in the basic region and a highly conserved His?CGlu?CArg motif, which is found in more than 50% of plant bHLHs, are predicted to bind DNA. The helix-loop-helix (HLH) region comprises two amphiphatic ?-helices, mainly consisting of hydrophobic amino acids, which are connected by a loop of variable length. Proteins containing the HLH motif often form homo- or heterodimers with other bHLH proteins, which is a prerequisite for DNA recognition and contributes to DNA-binding specificity.

Reference:

1. A. Feller, K. Machemer, E. L. Braun, E. Grotewold, Evolutionary and comparative analysis of MYB and bHLH plant transcription factors. Plant J 66, 94 (2011)

Cross-reference to other databases

The family is the same family of bHLH in PlantTFDB.

The family is the same family of bHLH in PlnTFDB.



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