Cys-rich regions in CBP and p300 called transcriptional adaptor or 'TAZ??. Each TAZ domain shows internal triplication of a Cys-x4-Cys-x8-His-x3-Cys motif. The TAZ1 domain in P300 and the TAZ2 (CH3) domain in CBP have each been shown to have four amphipathic helices, organized by three zinc-binding clusters with HCCC-type coordination.
1. R. N. De Guzman, H. Y. Liu, M. Martinez-Yamout, H. J. Dyson, P. E. Wright, Solution structure of the TAZ2 (CH3) domain of the transcriptional adaptor protein CBP. J Mol Biol 303, 243 (2000).
2. C. P. Ponting, D. J. Blake, K. E. Davies, J. Kendrick-Jones, S. J. Winder, ZZ and TAZ: new putative zinc fingers in dystrophin and other proteins. Trends Biochem Sci 21, 11 (1996).