To support the continuous development of PlantTFcat, please cite: Xinbin Dai, Senjuti Sinharoy, Michael K. Udvardi and Patrick X. Zhao, PlantTFcat: An Online Plant Transcription Factor and Transcriptional Regulator Categorization and Analysis Tool, BMC Bioinformatics, 2013, 14:321, doi:10.1186/1471-2105-14-321.
The Zhao Bioinformatics Laboratory
PlantTFcat: An Online Plant Transcription Factor and Transcriptional Regulator Categorization and Analysis Tool   
  About Analysis Family Help
Location:  Details of RB family

  RB
Family Type Putative novel transcription repressor
Plant Specific No
Functional Domains Protein-protein interacting domain
Must-have InterProScan Domain Pattern IPR002719 or IPR002720 or IPR015652
Prohibited InterProScan Domain Pattern -
Description

Rb that is central to its growth-inhibitory effects is its regulation of the E2F family of transcription factors, which are required for the expression of genes involved in the G1?CS transition. Highly conserved grooves B-box and A-box are present in its structure. The A-box portion appears to be required for the stable folding of the B box. Also A?CB interface is highly conserved suggesting that it may be involved in additional protein-binding. The A and B boxes each contain the cyclin-fold structural motif.

Reference:

1. J. O. Lee, A. A. Russo, N. P. Pavletich, Structure of the retinoblastoma tumour-suppressor pocket domain bound to a peptide from HPV E7. Nature 391, 859 (1998).

Cross-reference to other databases

The family is the same family of RB in PlnTFDB.



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