To support the continuous development of PlantTFcat, please cite: Xinbin Dai, Senjuti Sinharoy, Michael K. Udvardi and Patrick X. Zhao, PlantTFcat: An Online Plant Transcription Factor and Transcriptional Regulator Categorization and Analysis Tool, BMC Bioinformatics, 2013, 14:321, doi:10.1186/1471-2105-14-321.
The Zhao Bioinformatics Laboratory
PlantTFcat: An Online Plant Transcription Factor and Transcriptional Regulator Categorization and Analysis Tool   
  About Analysis Family Help
Location:  Details of KRAB-box family

  KRAB-box
Family Type Transcription factor interactor and regulator
Plant Specific No
Functional Domains DNA binding domain
Must-have InterProScan Domain Pattern IPR001909 or IPR003655
Prohibited InterProScan Domain Pattern IPR007087
Description

Cys2His2 (C2H2)-type zinc fingers are widespread DNA binding motifs in eukaryotic transcription factors. Two cysteine and two histidine residues located in certain positions bind zinc to stabilize the structure. The number of zinc fingers in a single protein can vary over a wide range, and single zinc finger containing transcription factors are only present in plant kingdom. KRAB (Kr??ppel associated box)-containing proteins are characterized by the presence of a DNA-binding domain made up of between 4 and over 30 zinc-finger motifs and a KRAB domain. The KRAB domain, located near the amino terminus of the protein, consists of one or both of the KRAB A box and the KRAB B box.

Reference:

1. R. Urrutia, KRAB-containing zinc-finger repressor proteins. Genome Biol 4, 231 (2003).

Cross-reference to other databases

The family is only defined in PlantTFcat.



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