To support the continuous development of PlantTFcat, please cite: Xinbin Dai, Senjuti Sinharoy, Michael K. Udvardi and Patrick X. Zhao, PlantTFcat: An Online Plant Transcription Factor and Transcriptional Regulator Categorization and Analysis Tool, BMC Bioinformatics, 2013, 14:321, doi:10.1186/1471-2105-14-321.
The Zhao Bioinformatics Laboratory
PlantTFcat: An Online Plant Transcription Factor and Transcriptional Regulator Categorization and Analysis Tool   
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Location:  Details of Homeodomain-LIKE family

  Homeodomain-LIKE
Family Type Transcription regulator
Plant Specific No
Functional Domains DNA binding domain
Must-have InterProScan Domain Pattern IPR009057
Prohibited InterProScan Domain Pattern IPR001005 IPR015495 IPR002492 IPR025898 IPR006447 IPR006712 IPR001356 IPR006456
Description

Plant homeobox genes can be classified into 14 classes based on sequence differentiation and fusion with characteristic codomain sequences. Homeobox genes encode a typical DNA-binding domain of 60 amino acids, known as homeodomain. Typically, homeodomain folds into characteristic 3D structure containing three alpha-helices, of which the second and third form a helix-turn-helix motif.
The homeodomain motif is very similar in sequence and structure to domains in a wide range of DNA-binding proteins, including Myb proteins, GARP response regulators, human telomeric proteins (hTRF1) etc. This entry indicated a family which have a very homodomain like DNA binding domain.

Reference:

1. J Mol Evol 65, 137 (2007) 2. Mukherjee, K., Brocchieri, L., and Burglin, T.R. (2009). A comprehensive classification and evolutionary analysis of plant homeobox genes. Mol Biol Evol 26, 2775-2794.
2. K. Hosoda, A. Imamura, E. Katoh, T. Hatta, M. Tachiki, H. Yamada, T. Mizuno, T. Yamazaki, Molecular structure of the GARP family of plant Myb-related DNA binding motifs of the Arabidopsis response regulators. Plant Cell 14, 2015 (2002).

Cross-reference to other databases

The family is the subfamily family of TALE in PlantTFDB.

The family is the superfamily family of HB in PlnTFDB.



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