To support the continuous development of PlantTFcat, please cite: Xinbin Dai, Senjuti Sinharoy, Michael K. Udvardi and Patrick X. Zhao, PlantTFcat: An Online Plant Transcription Factor and Transcriptional Regulator Categorization and Analysis Tool, BMC Bioinformatics, 2013, 14:321, doi:10.1186/1471-2105-14-321.
The Zhao Bioinformatics Laboratory
PlantTFcat: An Online Plant Transcription Factor and Transcriptional Regulator Categorization and Analysis Tool   
  About Analysis Family Help
Location:  Details of HMG family

  HMG
Family Type Chromatin remodeling & transcriptional activation
Plant Specific No
Functional Domains DNA binding domain
Must-have InterProScan Domain Pattern IPR009071 or IPR000116 or IPR000637
Prohibited InterProScan Domain Pattern IPR006780 IPR001606
Description

The HMG-box is an approximately 75-amino acid residue protein domain that occurs in all eukaryotic organisms. The HMG-box domain mediates DNA binding primarily through its interaction to the minor groove of DNA. Structural studies have demonstrated that an L-shaped fold of the domain formed by three alpha helices is conserved.

The long arm of which is consists of helix III and the N-terminal extended strand, whereas the short arm of the L-shape is composed of helices I and II in an ~80┬░angle between the arms. HMG-box proteins induce DNA bending upon binding to linear DNA, they often act as architectural facilitators in the assembly of nucleoprotein complexes involved in transcription, recombination, or other DNA-dependent processes.

Reference:

1. M. Stros, D. Launholt, K. D. Grasser, The HMG-box: a versatile protein domain occurring in a wide variety of DNA-binding proteins. Cell Mol Life Sci 64, 2590 (2007).

2. M. Antosch, S. A. Mortensen, K. D. Grasser, Plant proteins containing high mobility group box DNA-binding domains modulate different nuclear processes. Plant Physiol 159, 875 (2012).

Cross-reference to other databases

The family is the same family of HMG in PlnTFDB.



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