To support the continuous development of PlantTFcat, please cite: Xinbin Dai, Senjuti Sinharoy, Michael K. Udvardi and Patrick X. Zhao, PlantTFcat: An Online Plant Transcription Factor and Transcriptional Regulator Categorization and Analysis Tool, BMC Bioinformatics, 2013, 14:321, doi:10.1186/1471-2105-14-321.
The Zhao Bioinformatics Laboratory
PlantTFcat: An Online Plant Transcription Factor and Transcriptional Regulator Categorization and Analysis Tool   
  About Analysis Family Help
Location:  Details of FYR family

  FYR
Family Type Chromatin remodeling & transcription regulator
Plant Specific No
Functional Domains Putative modified histone binding
Must-have InterProScan Domain Pattern IPR003888 or IPR003889
Prohibited InterProScan Domain Pattern -
Description

The FYRN and FYRC sequence motifs are phenylalanine/tyrosine-rich regions of around 50 and 100 amino acids, respectively, which are found in a variety of chromatin-associated proteins. FYRN and FYRC motifs are found in association with modules that create or recognize histone modifications in proteins from a wide range of eukaryotes, and it is likely that in these proteins they have a conserved role related to some aspect of chromatin biology. Based on the structure, a binding rather than a catalytic function seems more likely. The nature of a potential ligand, however, remains unclear, as the FYR domain does not resemble any of the protein modules known to recognize potential binding partners such as modified histones.

Reference:

1. M. M. Garcia-Alai, M. D. Allen, A. C. Joerger, M. Bycroft, The structure of the FYR domain of transforming growth factor beta regulator 1. Protein Sci 19, 1432 (2010).

Cross-reference to other databases

The family is only defined in PlantTFcat.



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