To support the continuous development of PlantTFcat, please cite: Xinbin Dai, Senjuti Sinharoy, Michael K. Udvardi and Patrick X. Zhao, PlantTFcat: An Online Plant Transcription Factor and Transcriptional Regulator Categorization and Analysis Tool, BMC Bioinformatics, 2013, 14:321, doi:10.1186/1471-2105-14-321.
The Zhao Bioinformatics Laboratory
PlantTFcat: An Online Plant Transcription Factor and Transcriptional Regulator Categorization and Analysis Tool   
  About Analysis Family Help
Location:  Details of FHA-SMAD family

  FHA-SMAD
Family Type Transcription factor interactor and regulator
Plant Specific Yes
Functional Domains Protein-protein interacting Domain
Must-have InterProScan Domain Pattern IPR008984
Prohibited InterProScan Domain Pattern IPR007087 IPR008271
Description

The forkhead-associated (FHA) domain was originally described as a small domain in transcription factors with forkhead-type DNA binding domains. More recently, FHA domains have also been identified in protein kinases and other proteins that are not transcription factors such that most of the proteins now known to contain FHA domains function in cell cycle control. Biochemical and structural studies suggest that FHA domains are protein-protein interaction domains with specificity for phosphorylated targets. The structural studies have focused on the two FHA domains present within Rad53, a budding yeast DNA damage checkpoint kinase. Three-dimensional structures of the N-terminal FHA domain (N-FHA) bound to a phosphothreonine-containing peptide and of the C-terminal FHA domain (C-FHA) bound to a phosphotyrosine-containing peptide have been determined by crystallography and NMR, respectively, and show overall similar folds for the two FHA domains.

Reference:

1. E. S. Stavridi, Y. Huyen, I. R. Loreto, D. M. Scolnick, T. D. Halazonetis, N. P. Pavletich, P. D. Jeffrey, Crystal structure of the FHA domain of the Chfr mitotic checkpoint protein and its complex with tungstate. Structure 10, 891 (2002).

Cross-reference to other databases

The family is the synonymous family of FHA in PlnTFDB.



  © 2011-2013 by The Samuel Roberts Noble Foundation, Inc.; Designed for 1024x768 resolution