To support the continuous development of PlantTFcat, please cite: Xinbin Dai, Senjuti Sinharoy, Michael K. Udvardi and Patrick X. Zhao, PlantTFcat: An Online Plant Transcription Factor and Transcriptional Regulator Categorization and Analysis Tool, BMC Bioinformatics, 2013, 14:321, doi:10.1186/1471-2105-14-321.
The Zhao Bioinformatics Laboratory
PlantTFcat: An Online Plant Transcription Factor and Transcriptional Regulator Categorization and Analysis Tool   
  About Analysis Family Help
Location:  Details of BED-type(Zn) family

  BED-type(Zn)
Family Type Transcription factor/ chromatin remodeling
Plant Specific No
Functional Domains DNA binding
Must-have InterProScan Domain Pattern IPR003656
Prohibited InterProScan Domain Pattern IPR007087 IPR015880 IPR013087 IPR001841
Description

Zinc-finger proteins are one of the most common regulatory factors in eukaryotes. One subclass of these proteins has the recently described BED finger DNA-binding domain, characterized by the signature Cx2CxnHx3?C5[H/C] (xn is a variable spacer) and the presence of two highly conserved aromatic amino acids (tryptophan and phenylalanine) at its N terminus. BED finger proteins are thought to function as either transcription activators or repressors by modifying local chromatin structure on binding to GC-rich sequences.

Reference:

1. L. Aravind, The BED finger, a novel DNA-binding domain in chromatin-boundary-element-binding proteins and transposases. Trends Biochem Sci 25, 421 (2000).

2. M. Saghizadeh, N. B. Akhmedov, C. K. Yamashita, Y. Gribanova, V. Theendakara, E. Mendoza, S. F. Nelson, A. V. Ljubimov, D. B. Farber, ZBED4, a BED-type zinc-finger protein in the cones of the human retina. Invest Ophthalmol Vis Sci 50, 3580 (2009).

Cross-reference to other databases

The family is only defined in PlantTFcat.



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