To support the continuous development of PlantTFcat, please cite: Xinbin Dai, Senjuti Sinharoy, Michael K. Udvardi and Patrick X. Zhao, PlantTFcat: An Online Plant Transcription Factor and Transcriptional Regulator Categorization and Analysis Tool, BMC Bioinformatics, 2013, 14:321, doi:10.1186/1471-2105-14-321.
The Zhao Bioinformatics Laboratory
PlantTFcat: An Online Plant Transcription Factor and Transcriptional Regulator Categorization and Analysis Tool   
  About Analysis Family Help
Location:  Details of A20-like family

  A20-like
Family Type Putative novel transcription regulator
Plant Specific No
Functional Domains Putative DNA binding domain
Must-have InterProScan Domain Pattern IPR002653 or IPR000058
Prohibited InterProScan Domain Pattern IPR015880 IPR007087
Description

The A20 proteins have a novel class of Cys2/Cys2 zinc finger domain. It may be present in tandem repeat or singularly. In animals it has been shown to modulate NF-kB signaling pathway. Recently it has been shown that 4-ZnF domain in A20 interact with K63-linked Ub. But weather this domain can bind to DNA directly is not determine yet and specific function of A20 Znf proteins in plant is also yet to be reported.

Reference:

1. P. C. Evans, E. R. Taylor, J. Coadwell, K. Heyninck, R. Beyaert, P. J. Kilshaw, Isolation and characterization of two novel A20-like proteins. Biochem J 357, 617 (2001)

2. I. Bosanac, I. E. Wertz, B. Pan, C. Yu, S. Kusam, C. Lam, L. Phu, Q. Phung, B. Maurer, D. Arnott, D. S. Kirkpatrick, V. M. Dixit, S. G. Hymowitz, Ubiquitin binding to A20 ZnF4 is required for modulation of NF-kappaB signaling. Mol Cell 40, 548 (2010)

Cross-reference to other databases

The family is only defined in PlantTFcat.



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